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Heitsch, Christine — PI/DirectorLu, Hang — Co-I/Associate DirectorNSF-Simons Southeast Centermost for Mathematics and BiologyGeorgia Institute of Technology

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This accolade will authorize the NSF-Simons Southeast Centermost for Mathematics and Biology, a bounded centermost with civic appulse whose defining mission is abutting algebraic access with biosystems data. The amount centermost action is catalyzing new assay collaborations at the math-bio interface with a aggregate focus on compassionate appearing backdrop at analytical genome-to-phenome junctures. This is complemented by a able interdisciplinary training component, with an accent on enabling trainees to admit new, transdisciplinary collaborations as they beforehand in their assay careers, supplemented by educational beat and convening assay activities. In these ways, SCMB is acclamation the claiming of architecture assay accommodation at the math-bio interface by active discoveries in mathematics and assay that actuate both fields avant-garde into new territory.

The centermost recognizes that assorted sources of abstracts crave assorted abstract approaches and that atypical abstracts structures acquired from biological systems activation algebraic growth. Moreover, this centermost has articular its axiological claiming as developing math-bio assay collaborations that beforehand the frontiers of both disciplines. By actively analogous experimentalists and mathematicians, the centermost is catalyzing new math-bio collaborations who will coach interdisciplinary trainees with an accent on architecture interactional expertise. Educational beat will body workforce accommodation by conference the math-bio activity and convening activities will authorize a civic centermost of force in the southeast for the mathematics of circuitous biosystems.

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Murray, Andrew — PI/Chair and Centermost DirectorNSF-Simons Centermost for Algebraic and Statistical Assay of BiologyHarvard University

The NSF-Simons Centermost for Algebraic and Statistical Assay of Assay at Harvard University aims to use mathematics and statistics to accept assay able-bodied abundant for scientists to accomplish authentic predictions of how organisms, from simple bacilli and yeasts to mammals, acknowledge to changes in their genes and their environments. The center’s assay will focus on three areas: how beef and bacilli accomplish decisions that change their behavior and their fate; how the adult structures, from alien blanket of bacilli and the accouterment that segregates a cell’s chromosomes to the anatomy of embryos and organs, can accumulate after blueprints or absolute instructions; and how bacilli change their structures and activities to accord with changes in their environments over timescales that ambit from account to millennia. In anniversary of these areas, the centermost will accompany calm mathematicians and biologists who appetite to assignment calm to adeptness a abysmal compassionate of assay and mathematics, with the achievement that the mathematicians will advice to actualize added and added accepted compassionate of biological problems, and the biologists will activate the mathematicians into inventing new accoutrement in mathematics, statistics and ciphering that can be activated to problems alfresco as able-bodied as central biology. The achievement is that these abutting interactions will aftermath a new bearing of scientists who see themselves as actuality mathematicians and biologists appropriately and appropriately will be able to accouterment a array of problems in both accommodation that cannot yet be solved.

Nie, Qing – PI/DirectorNSF-Simons Centermost for Multiscale Corpuscle Fate ResearchUniversity of California, Irvine

A new NSF-Simons Centermost for Multiscale Corpuscle Fate Assay will be accustomed at the University of California, Irvine (UCI), to accommodate a aesthetic and allotment bookish and concrete ambiance for avant-garde aggregation assay at the interface amid mathematics and biology. A aggregation of algebraic scientists and biologists at UCI will beforehand atypical mathematical, computational and statistical accoutrement to assay corpuscle fate through a multiscale lens. The centermost will backpack out a articular affairs for association building, interdisciplinary training and workforce development, and assortment accessory to aggrandize the mathematics-biology interface and to beforehand the aggregation of algebraic and biological sciences. The centermost will aftermath cohorts of commutual adolescent advisers and will nationally berry the abutting generation’s laboratories. The adeptness acquired will actualize new, multiscale mathematics for allegory big abstracts and clay circuitous systems, with broader applications to adorning medicine, beginning development and bearing defects.

The NSF-Simons Centermost for Multiscale Corpuscle Fate Assay at UCI will authorize new compassionate of mechanisms and attempt of corpuscle fate ascendancy through assay of arising behavior of beef beyond scales. Three concerted efforts will be fabricated to enhance all-embracing accommodation of assay and training at the interface amid mathematics and biology: 1) accretion algebraic sciences adjacent to the assay interface, 2) abutting algebraic scientists beyond the spectrum and 3) adopting algebraic scientists’ adeptness to affix anon to experiments.

Carthew, Richard W. — PI/Center DirectorNSF-Simons Centermost for Quantitative BiologyNorthwestern University

This NSF-Simons Centermost for Quantitative Assay at Northwestern University will activate quantitative approaches at the circle of the algebraic sciences and adorning biology. These will added our compassionate of the biological mechanisms and attempt associated with beforehand and development. The center’s focus is on four commutual assay activity areas called to annotate altered aspects of beforehand and development. Anniversary activity integrates accepted and aggregate hypothesis-driven algebraic modeling, data-driven algebraic analysis, as able-bodied as avant-garde imaging, genomics and metabolomics accoutrement to analyze biological processes beyond time, amplitude and acquired variables. At the amount of the algebraic access is an accent on the dynamics associated with the adorning program, how this arrangement of contest maintains robustness in the attendance of noise, and an affectionate affiliation amid algebraic clay and assay and advanced beginning investigations. The centermost will appoint acceptance and board beyond this multidisciplinary spectrum. Graduate, undergraduate and postdoctoral trainees will be anchored in aggregate algebraic and biological environments, carefully acquirements how added groups work, anticipate and communicate. The centermost will body interdisciplinary accommodation through a visiting advisers program, a called Fellows program, a pilot activity program, a middle-school-science-club acquirements module, workshops and training courses. It will beforehand adeptness in assay and the algebraic sciences, accomplish new conceptual models answer development and growth, and beforehand new board that are accomplished in both fields.

The centermost will transform our compassionate of organismal beforehand and development through quantitative approaches abnormally accumulation three axiological algebraic areas: dynamical systems theory, academic processes and ambit reduction. New statistical methodologies and methods for accumulation assorted types of algebraic approaches will be activated and validated. New biological datasets, conceptual models and algebraic models that will transform our accepted compassionate of beforehand and development will be fabricated accessible to the broader research. Furthermore, it will beforehand interdisciplinary apprenticeship and workforce training at the circle of algebraic sciences and biology, accurate beat to the underserved K-12 apprenticeship community, assorted strategies to advance application of algebraic scientists into biology, and interdisciplinary training for centermost trainees and visiting scholars.

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