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NEW YORK, May 11, May 11, 2020 (GLOBE NEWSWIRE via COMTEX) — Accepted Ocaliva net sales of $72.7 actor in the aboriginal division 2020, apery 40% beforehand over the above-mentioned year division

Regulatory and bartering affairs on clue for tentatively appointed FDA advising board affair and post-approval barrage of OCA in alarmist fibrosis due to NASH

Company acknowledgment to COVID-19 advised to ensure business alternation and abutment accession chain, analytic development and barrage address activities

Conference alarm appointed for 8:30 a.m. ET today

Intercept Pharmaceuticals, Inc. (Nasdaq: ICPT), a biopharmaceutical aggregation focused on the development and commercialization of atypical assay to amusement accelerating non-viral alarmist diseases, today appear its banking after-effects for the division concluded March 31, 2020.

“We accept had a alive alpha to the year actuality at Intercept,” said Mark Pruzanski, M.D., President and Chief Executive Officer of Intercept. “In the aboriginal division we saw bigger than advancing Ocaliva net sales in our PBC business, which were accurate by connected able absolute decree trends and abundantly college than accepted account appeal appear the end of the division as assertive barter responded to the ambiguity of the aboriginal COVID-19 period. Like all companies, we are adjusting to the new ambiance created by the all-around pandemic, and I am absolute appreciative of our team’s response. We accept taken a cardinal of important accomplish advised to ensure the candor of our analytic trials, beforehand alternation in our accession alternation and beforehand our NASH barrage alertness activities, all while continuing to bear solid after-effects and attention the bloom and assurance of our employees. We abide absolute focused on the ambition of bringing the aboriginal accustomed assay to patients with avant-garde fibrosis due to NASH and apprehend to be able-bodied able for our accessible FDA advising board meeting, which is tentatively appointed for June 9, 2020.”

Selected Aboriginal Division 2020 Banking After-effects

Revenues

We accustomed $72.7 actor in absolute acquirement in the aboriginal division of 2020, as compared to $52.2 actor in absolute acquirement in the above-mentioned year quarter. Ocaliva net sales in the aboriginal division of 2020 were comprised of U.S. net sales of $50.8 actor and ex-U.S. net sales of $21.9 million, as compared to U.S. net sales of $38.0 actor and ex-U.S. net sales of $13.8 actor in the above-mentioned year quarter. Absolute acquirement in the aboriginal division of 2019 included about $0.4 actor of licensing revenue.

Operating Costs

Our bulk of sales were $0.9 actor in the aboriginal division of 2020, as compared to $0.6 actor in the above-mentioned year quarter. Our bulk of sales for the abode concluded March 31, 2020 and 2019 consisted primarily of packaging, labeling, abstracts and accompanying expenses.

Our selling, accepted and authoritative costs added to $98.6 actor in the aboriginal division of 2020, up from $77.2 actor in the above-mentioned year quarter. The access was primarily apprenticed by authoritative beforehand and added activities associated with our alertness for the abeyant approval and commercialization of OCA for alarmist fibrosis due to NASH.

Our assay and development costs decreased to $56.7 actor in the aboriginal division of 2020, bottomward from $58.4 actor in the above-mentioned year quarter. The bashful abatement was primarily apprenticed by lower NASH development costs, including a abridgement in costs associated with screening and randomization activities for our REVERSE and REGENERATE studies, which were absolutely enrolled consecutive to the end of the above-mentioned year quarter.

In the abode concluded March 31, 2020 and 2019, we recorded $156.1 actor and $136.2 million, respectively, in absolute operating costs and $142.9 actor and $120.3 million, respectively, in non-GAAP adapted operating expenses, which excludes non-cash stock-based advantage bulk of $12.5 actor and $14.9 million, respectively, and abrasion bulk of $0.7 actor and $1.0 million, respectively.

References in this columnist absolution to “non-GAAP adapted operating expenses” beggarly our absolute operating expenses, as affected and presented in accordance with U.S. About Accepted Accounting Principles (“GAAP”), adapted for the furnishings of two non-cash items: stock-based advantage and depreciation. See “Non-GAAP Banking Measures” below. A adaptation of non-GAAP adapted operating costs to absolute operating costs for all absolute periods presented is included beneath beneath the branch “Reconciliation of Non-GAAP Adapted Operating Costs to Absolute Operating Expenses.”

Interest Bulk

Interest bulk in the abode concluded March 31, 2020 and 2019 was $11.8 actor and $7.8 million, respectively. For the division concluded March 31, 2020, assimilation bulk accompanying to the $460.0 actor accumulated arch bulk of 3.25% Convertible Senior Notes due 2023 that we issued in July 2016 and the $230 actor accumulated arch bulk of 2.00% Convertible Senior Notes due 2026 (the “2026 Convertible Notes”) that we issued in May 2019. For the division concluded March 31, 2019, assimilation bulk accompanying alone to the 2023 Convertible Notes.

Net Accident

In the aboriginal division of 2020 we appear a net accident of $93.0 million, an access compared to a net accident of $90.3 actor in the aboriginal division 2019.

Cash Position

As of March 31, 2020, we had cash, banknote equivalents, belted cash, and advance debt balance accessible for auction of about $554.0 million. As of December 31, 2019, we had cash, banknote equivalents, belted cash, and advance debt balance accessible for auction of about $657.4 million.

2020 Banking Advice

The FDA has set a Decree Biologic User Fee Act (“PDUFA”) ambition activity date of June 26, 2020 for the accomplishment of its assay of our NDA gluttonous approval of OCA for alarmist fibrosis due to NASH. As a aftereffect of the uncertainties apropos to COVID-19 and the barrage of OCA in fibrosis due to NASH and their abeyant appulse on our 2020 banking performance, we are not accouterment abounding year 2020 net sales guidance.

We abide to apprehend non-GAAP adapted operating costs for 2020 to be in the ambit of $560 actor to $600 million, assimilation our investments to abutment the barrage of OCA for alarmist fibrosis due to NASH, our bartering efforts in primary biliary cholangitis (“PBC”), our analytic development and activity programs, and our added operating activities. Our non-GAAP adapted operating costs advice assumes the approval of our NDA for alarmist fibrosis due to NASH by the FDA on or about the PDUFA ambition activity date.

See “Non-GAAP Banking Measures” below. A quantitative adaptation of projected non-GAAP adapted operating costs to absolute operating costs is not accessible afterwards absurd accomplishment primarily due to our disability to adumbrate with reasonable authoritativeness the bulk of approaching stock-based advantage expense.

Conference Alarm on May 11, 2020 at 8:30 a.m. ET

We are hosting our aboriginal division 2020 banking after-effects appointment alarm and webcast on Monday, May 11, 2020 at 8:30 a.m. ET. The appointment alarm will be accessible on the broker folio of our website at http://ir.interceptpharma.com or by calling (855) 232-3919 (toll-free domestic) or (315) 625-6894 (international) passcode 2458176. A epitomize of the alarm will be accessible on our website anon afterward the accomplishment of the alarm and will be accessible for two weeks.

About Intercept

Intercept is a biopharmaceutical aggregation focused on the development and commercialization of atypical assay to amusement accelerating non-viral alarmist diseases, including primary biliary cholangitis (PBC) and nonalcoholic steatohepatitis (NASH). Founded in 2002 in New York, Intercept has operations in the United States, Europe and Canada. For added information, amuse appointment www.interceptpharma.com or affix with the aggregation on Twitter and LinkedIn.

Non-GAAP Banking Measures

This columnist absolution presents non-GAAP adapted operating costs on a absolute and projected basis. For the periods presented, non-GAAP adapted operating costs exclude from absolute operating expenses, as affected and presented in accordance with GAAP, the furnishings of two non-cash items: stock-based advantage and depreciation. Non-GAAP adapted operating costs is a banking admeasurement that has not been able in accordance with GAAP. Accordingly, investors should accede non-GAAP adapted operating costs in accession to, but not as a acting for, absolute operating costs that we account and present in accordance with GAAP. Amid added things, our administering uses non-GAAP adapted operating costs to authorize budgets and operational goals and to administer our business. Added companies may ascertain or use this admeasurement in altered ways. We accept that the presentation of non-GAAP adapted operating costs provides investors and administering with accessible added advice apropos to operating accomplishment and trends. As of March 31, 2020, non-GAAP adapted operating costs no best afar from absolute operating costs the furnishings of non-cash operating charter bulk cost, and non-GAAP adapted operating costs for all periods included herein accept been presented accordingly. A table reconciling non-GAAP adapted operating costs to absolute operating costs for all absolute periods presented is included beneath beneath the branch “Reconciliation of Non-GAAP Adapted Operating Costs to Absolute Operating Expenses”. A quantitative adaptation of projected non-GAAP adapted operating costs to absolute operating costs is not accessible afterwards absurd accomplishment primarily due to our disability to adumbrate with reasonable authoritativeness the bulk of approaching stock-based advantage expense.

About Alarmist Fibrosis due to NASH

Nonalcoholic steatohepatitis (NASH) is a austere accelerating alarmist ache acquired by boundless fat accession in the alarmist that induces abiding inflammation, consistent in accelerating fibrosis (scarring) that can advance to cirrhosis, closing alarmist failure, blight and death. Avant-garde fibrosis is associated with a essentially college accident of liver-related anguish and bloodshed in patients with NASH and, as aboriginal as 2020, the ache is projected to become the arch account of alarmist transplants in the United States. There are currently no medications accustomed for the assay of NASH.

About the REGENERATE Abstraction

REGENERATE is a Phase 3, randomized, double-blind, placebo-controlled, multicenter abstraction assessing the assurance and adeptness of obeticholic acerbic (OCA) on analytic outcomes in patients with alarmist fibrosis due to NASH. A pre-specified 18-month assay was conducted to appraise the aftereffect of OCA on alarmist assay comparing ages 18 biopsies with baseline. REGENERATE has completed ambition accepting for the analytic outcomes cohort, with 2,480 developed NASH patients randomized over 300 able centers worldwide, and will abide through analytic outcomes for assay and description of analytic benefit. The end-of-study assay will appraise the aftereffect of OCA on all-cause bloodshed and liver-related analytic outcomes, as able-bodied as its abiding safety.

About Ocaliva(R) (obeticholic acid)

Ocaliva is adumbrated in the United States for the assay of primary biliary cholangitis (PBC) in accumulated with ursodeoxycholic acerbic (UDCA) in adults with an bare acknowledgment to UDCA, or as monotherapy in adults clumsy to abide UDCA.

This adumbration is accustomed beneath the accelerated approval alleyway based on a abridgement in acrid phosphatase (ALP) as a agent endpoint which is analytic acceptable to adumbrate analytic benefit, including an advance in alarmist displace free-survival. An advance in adaptation or disease-related affection has not been established. Connected approval for this adumbration may be accidental aloft assay and description of analytic account in acknowledging trials. We are administering a Phase 4 analytic outcomes trial, which we accredit to as our COBALT trial, of OCA in patients with PBC with the ambition of acknowledging analytic account on a post-marketing basis.

In December 2016, Ocaliva accustomed codicillary business allotment in Europe for the assay of PBC in accumulated with UDCA in adults with an bare acknowledgment to UDCA or as monotherapy in adults clumsy to abide UDCA, conditioned aloft us accouterment added abstracts post-approval to affirm benefit. For abundant assurance advice for Ocaliva 5 mg and 10 mg tablets including posology and acclimation of administration, appropriate warnings, biologic interactions and adverse biologic reactions, amuse see the European Summary of Artefact Characteristics that can be begin on www.ema.europa.eu.

U.S. IMPORTANT SAFETY INFORMATION FOR OCALIVA IN PBC

WARNING: HEPATIC DECOMPENSATION AND FAILURE IN INCORRECTLY DOSED PBC PATIENTS WITH CHILD-PUGH CLASS B OR C OR DECOMPENSATED CIRRHOSIS

— In postmarketing reports, hepatic decompensation and failure, in some cases fatal, accept been appear in patients with Primary Biliary Cholangitis (PBC) with decompensated cirrhosis or Child-Pugh Class B or C hepatic crime back OCALIVA was dosed added frequently than recommended.

— The recommended starting dosage of OCALIVA is 5 mg already account for patients with Child-Pugh Class B or C hepatic crime or a above-mentioned decompensation event.

Contraindications

OCALIVA is contraindicated in PBC patients with complete biliary obstruction.

Warnings and Precautions

Hepatic Decompensation and Abortion in Incorrectly-Dosed PBC Patients with Child-Pugh Class B or C or Decompensated Cirrhosis

In postmarketing reports, hepatic decompensation and failure, in some cases fatal, accept been appear in PBC patients with decompensated cirrhosis or Child-Pugh B or C hepatic crime back OCALIVA was dosed added frequently than the recommended starting dosage of 5 mg already weekly. Appear cases about occurred aural 2 to 5 weeks afterwards starting OCALIVA and were characterized by an astute access in absolute bilirubin and/or ALP concentrations in affiliation with analytic signs and affection of hepatic decompensation (e.g., ascites, jaundice, gastrointestinal bleeding, deepening of hepatic encephalopathy).

Routinely adviser patients for progression of PBC disease, including liver-related complications, with class and analytic assessments. Dosage adjustment, abeyance or cessation may be required. Close ecology is recommended for patients at an added accident of hepatic decompensation. Astringent intercurrent illnesses that may aggravate renal action or account aridity (e.g., gastroenteritis), may aggravate the accident of hepatic decompensation. Interrupt assay with OCALIVA in patients with class or analytic affirmation of deepening alarmist action advertence accident of decompensation, and adviser the patient’s alarmist function. Accede alternate OCALIVA in patients who accept accomplished clinically cogent liver-related adverse reactions. Discontinue OCALIVA in patients who advance complete biliary obstruction.

Liver-Related Adverse Reactions

Dose-related, liver-related adverse reactions including jaundice, deepening ascites and primary biliary cholangitis blaze accept been empiric in analytic trials, as aboriginal as one ages afterwards starting assay with OCALIVA 10 mg already circadian up to 50 mg already circadian (up to 5-times the accomplished recommended dosage). Adviser PBC patients during assay with OCALIVA for elevations in alarmist biochemical tests and for the development of liver-related adverse reactions.

Severe Pruritus

Severe pruritus was appear in 23% of PBC patients in the OCALIVA 10 mg arm, 19% of PBC patients in the OCALIVA titration arm, and 7% of PBC patients in the placebo arm in a 12-month double-blind randomized controlled balloon of 216 PBC patients. Astringent pruritus was authentic as acute or boundless itching, interfering with activities of circadian living, or causing astringent beddy-bye disturbance, or intolerable discomfort, and about acute medical interventions. Accede analytic appraisal of PBC patients with new access or deepening astringent pruritus. Administering strategies accommodate the accession of acerbity acerbic resins or antihistamines, OCALIVA dosage reduction, and/or acting abeyance of OCALIVA dosing.

Reduction in HDL-C

Patients with PBC about display hyperlipidemia characterized by a cogent acclivity in absolute cholesterol primarily due to added levels of high-density lipoprotein-cholesterol (HDL-C). Dose-dependent reductions from baseline in beggarly HDL-C levels were empiric at 2 weeks in OCALIVA-treated PBC patients, 20% and 9% in the 10 mg and titration arms, respectively, compared to 2% in the placebo arm. Adviser PBC patients for changes in serum lipid levels during treatment. For PBC patients who do not acknowledge to OCALIVA afterwards 1 year at the accomplished recommended dosage that can be acceptable (maximum of 10 mg already daily), and who acquaintance a abridgement in HDL-C, counterbalance the abeyant risks adjoin the allowances of continuing treatment.

Adverse Reactions

The best accepted adverse reactions from capacity demography OCALIVA for PBC were pruritus, fatigue, belly affliction and discomfort, rash, oropharyngeal pain, dizziness, constipation, arthralgia, thyroid action abnormality, and eczema.

Drug Interactions

Bile Acerbic Bounden Resins

Bile acerbic bounden resins such as cholestyramine, colestipol, or colesevelam adsorb and abate acerbity acerbic assimilation and may abate the absorption, systemic exposure, and adeptness of OCALIVA. If demography a acerbity acerbic bounden resin, booty OCALIVA at atomic 4 hours afore or 4 hours afterwards demography the acerbity acerbic bounden resin, or at as abundant an breach as possible.

Warfarin

The All-embracing Normalized Ratio (INR) decreased afterward coadministration of warfarin and OCALIVA. Adviser INR and acclimatize the dosage of warfarin, as needed, to beforehand the ambition INR ambit back coadministering OCALIVA and warfarin.

CYP1A2 Substrates with Attenuated Ameliorative Basis

Obeticholic acid, the alive additive in OCALIVA, may access the acknowledgment to accessory drugs that are CYP1A2 substrates. Ameliorative ecology of CYP1A2 substrates with a attenuated ameliorative basis (e.g. theophylline and tizanidine) is recommended back coadministered with OCALIVA.

Inhibitors of Acerbity Alkali Address Pump

Avoid accessory use of inhibitors of the acerbity alkali address pump (BSEP) such as cyclosporine. Accessory medications that arrest canalicular film acerbity acerbic transporters such as the BSEP may aggravate accession of conjugated acerbity salts including taurine conjugate of obeticholic acerbic in the alarmist and aftereffect in analytic symptoms. If accessory use is accounted necessary, adviser serum transaminases and bilirubin.

Please see Abounding Prescribing Information, including Boxed WARNING and Medication Guide for OCALIVA.

To address SUSPECTED ADVERSE REACTIONS, acquaintance Intercept Pharmaceuticals, Inc. at 1-844-782-ICPT or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Cautionary Note Apropos Forward-Looking Statements

This columnist absolution contains advanced statements, including, but not bound to, statements apropos the progress, timing and after-effects of our analytic trials, including our analytic trials for the assay of nonalcoholic steatohepatitis (“NASH”), the assurance and adeptness of our accustomed product, Ocaliva (obeticholic acerbic or “OCA”) for primary biliary cholangitis (“PBC”), and our artefact candidates, including OCA for alarmist fibrosis due to NASH, the timing and accepting of our authoritative filings and the abeyant approval of OCA for alarmist fibrosis due to NASH or any added break in accession to PBC, the timing and abeyant bartering success of OCA and any added artefact candidates we may advance and our strategy, approaching operations, approaching banking position, approaching revenue, projected costs, banking guidance, prospects, affairs and objectives.

These statements accumulated advanced statements aural the acceptation of Section 27A of the Balance Act of 1933, as amended, and Section 21E of the Balance Exchange Act of 1934, as amended. The words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “target,” “potential,” “will,” “would,” “could,” “should,” “possible,” “continue” and agnate expressions are advised to analyze advanced statements, although not all advanced statements accommodate these anecdotic words. Readers are cautioned not to abode disproportionate assurance on these advanced statements, which allege alone as of the date of this release, and we undertake no obligation to amend any advanced account except as appropriate by law. These advanced statements are based on estimates and assumptions by our administering that, although believed to be reasonable, are inherently ambiguous and accountable to a cardinal of risks. The afterward represent some, but not necessarily all, of the factors that could account absolute after-effects to alter materially from absolute after-effects or those advancing or predicted by our advanced statements: the appulse of COVID-19, including any appulse on our net sales, non-GAAP adapted operating costs or banking position, accompanying quarantines and government actions, delays apropos to our authoritative applications, disruptions apropos to our advancing analytic trials or involving our arrangement assay organizations, abstraction sites or added analytic partners, disruptions apropos to our accession alternation or involving our third-party manufacturers, distributors or added administration partners, adeptness closures or added restrictions, and the admeasurement and continuance thereof; our adeptness to auspiciously commercialize Ocaliva for PBC; our adeptness to beforehand our authoritative approval of Ocaliva for PBC in the United States, Europe, Canada, Israel, Australia and added jurisdictions in which we accept or may accept business authorization; the initiation, timing, cost, conduct, advance and after-effects of our assay and development activities, preclinical studies and analytic trials, including any issues, delays or failures in anecdotic patients, enrolling patients, alleviative patients, application patients, affair specific endpoints in the jurisdictions in which we intend to seek approval or commutual and appropriate advertisement the after-effects of our NASH or PBC analytic trials; our adeptness to appropriate and cost-effectively book for and access authoritative approval of our artefact candidates, including the authoritative approval of our New Biologic Application for alarmist fibrosis due to NASH; any advising board advocacy that our artefact candidates, including OCA for alarmist fibrosis due to NASH, should not be accustomed or accustomed alone beneath assertive conditions; any assurance that the authoritative applications and consecutive advice we abide for our artefact candidates, including OCA for alarmist fibrosis due to NASH, do not accommodate able analytic or added abstracts or accommodated applicative authoritative requirements for approval; altitude that may be imposed by authoritative authorities on our business approvals for our articles and artefact candidates, including OCA for alarmist fibrosis due to NASH, such as the charge for analytic outcomes abstracts (and not aloof after-effects based on accomplishment of a agent endpoint), any accident acknowledgment programs such as a REMS, and any accompanying restrictions, limitations and/or warnings independent in the characterization of any of our articles or artefact candidates; any abeyant ancillary furnishings associated with Ocaliva for PBC, OCA for alarmist fibrosis due to NASH or our added artefact candidates that could adjournment or anticipate approval, crave that an accustomed artefact be taken off the market, crave the admittance of assurance warnings or precautions, or contrarily absolute the auction of such artefact or artefact candidate; our adeptness to authorize and beforehand relationships with, and the accomplishment of, third-party manufacturers, arrangement assay organizations and added vendors aloft whom we are essentially abased for, amid added things, the accomplish and accession of our products, including Ocaliva for PBC and, if approved, OCA for alarmist fibrosis due to NASH, and our analytic balloon activities; our adeptness to identify, advance and auspiciously commercialize our articles and artefact candidates, including our adeptness to appropriate and auspiciously barrage OCA for alarmist fibrosis due to NASH, if approved; our adeptness to access and beforehand bookish acreage aegis for our articles and artefact candidates, including our adeptness to cost-effectively file, prosecute, avert and accomplish any apparent claims or added bookish acreage rights; the admeasurement and beforehand of the markets for our articles and artefact candidates and our adeptness to serve those markets; the bulk of bazaar accepting of Ocaliva for PBC and, if approved, OCA for alarmist fibrosis due to NASH or our added artefact candidates amid physicians, patients and healthcare payors; the availability of able advantage and agreement from authoritative and clandestine healthcare payors for our products, including Ocaliva for PBC and, if approved, OCA for alarmist fibrosis due to NASH, and our adeptness to access able appraisement for such products; our adeptness to authorize and beforehand able sales, business and administration capabilities, either anon or through collaborations with third parties; antagonism from absolute drugs or new drugs that become available; our adeptness to anticipate arrangement failures, abstracts breaches or violations of abstracts aegis laws; costs and outcomes apropos to any disputes, authoritative inquiries or investigations, acknowledged affairs or litigation, including any securities, bookish property, employment, artefact accountability or added litigation; our collaborators’ acclamation to accompany research, development and commercialization activities; our adeptness to authorize and beforehand relationships with collaborators with development, authoritative and commercialization expertise; our charge for and adeptness to accomplish or access added financing; our estimates apropos approaching expenses, revenues and basic requirements and the accurateness thereof; our use of banknote and concise investments; our adeptness to acquire, authorization and advance in businesses, technologies, artefact candidates and products; our adeptness to allure and absorb key cadre to administer our business effectively; our adeptness to administer the beforehand of our operations, infrastructure, personnel, systems and controls; our adeptness to access and beforehand able allowance coverage; the appulse of accepted U.S. and adopted economic, industry, market, authoritative or political conditions, including the abeyant appulse of Brexit; and the added risks and uncertainties articular in our alternate filings filed with the U.S. Balance and Exchange Commission, including our Annual Address on Form 10-K for the year concluded December 31, 2019.

Contact

For added advice about Intercept, amuse contact:

Lisa DeFrancesco

1-646-565-4833

[email protected]

Christopher Frates

1-646-757-2371

[email protected]

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