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This adviser provides advice on advancing production-quality abstracts and argument files. The instructions administer alone if your arrangement has been accustomed in assumption for advertisement and an editor has asked you to upload production-quality material.

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Before your arrangement can be formally accustomed for advertisement and anesthetized to our subediting, art and assembly departments, you will charge to upload cyberbanking files of your text, figures, Extended Abstracts abstracts and tables, and Added Advice (if any) to our server. You will additionally charge to upload scanned copies of any forms and declarations requested by the beat appointment for signing (these may be faxed if scanning is not possible, with the fax labelled acutely with the agnate columnist name and arrangement advertence number).

Please chase these guidelines to ensure that your final files are complete and in the absolute format. This will acceleration the administration of your arrangement afterwards it is accepted, abate delays and abbreviate abeyant errors.

If you are clumsy to upload production-quality files to our server, you should acquaintance Nature’s London appointment for capacity of how files may be beatific on disk, although you should be acquainted that online acquiescence is the adopted avenue and acquiescence by added agency may adjournment accepting and/or advertisement of your paper.

At acceptance, amuse upload the argument (this includes legends for book abstracts and Extended Abstracts figures, complete book tables, and titles and legends alone for Extended Abstracts tables, but excludes book abstracts and Extended Abstracts abstracts and tables themselves) of your cardboard to our server calm with your production-quality abstracts and Extended Abstracts abstracts and tables as abstracted files, and Added Information, if any.

Important. It is the author’s albatross to ensure that the adaptation uploaded is the final, accustomed adaptation of the paper.

Instructions for formatting and agreeable of the argument are in the arrangement formatting guide.

Our adopted architecture for argument is Microsoft Word with the actualization tags removed.

If you acquire able your cardboard application TeX/LaTeX, we will charge to catechumen this to Word afterwards acceptance, afore your cardboard in typeset. For cross-reference purposes, amuse catechumen to PDF architecture and upload the PDF in accession to the TeX/LaTeX book at final submission.

Authors appointment LaTeX files may use any of the accustomed chic files such as article.cls, revtex.cls, aastex.cls or amsart.cls. Amuse abolish all claimed macros, and abstain loading non-standard packages. All textual absolute of the cardboard (including tables, amount captions, online methods, etc.) should be in cyberbanking form, as a distinct file. Graphics should not be alleged during compilation; they should be supplied alone according to the guidelines on amount alertness below. There is no charge to absorb time visually formatting the manuscript. Amuse use afterwards commendation styles alone and ensure that the citations are numbered according to the adjustment they arise in the argument (not alphabetically). References should be included aural the arrangement book itself. Authors who ambition to use BibTeX to adapt their references should archetype the advertence annual from the .bbl book that BibTeX generates and adhesive it into the capital arrangement .tex book (and annul the associated bibliography and bibliographystyle commands). As a final precaution, authors should ensure that the complete .tex book compiles auspiciously on their own arrangement with no errors or warnings, afore submission.

Articles should be ordered in the sequence: title, authors, affiliations (plus present addresses), adventurous aboriginal paragraph, capital text, references, tables, amount legends, (online-only) Methods (plus any associated references; abstracts and cipher availability statements included at end of online Methods), acknowledgements, columnist contributions, aggressive absorption declaration, added advice (containing added advice band (if any) and agnate columnist line), Extended Abstracts amount legends and Extended Abstracts table titles and footnotes (any references altered to the Extended Abstracts should be added to the end of the online-only advertence list).

We adopt the use throughout of a ‘standard’ font, finer 12-point Times New Roman. For superscripts or subscripts, amuse administer absolute super/subscript format; do not use ‘raised’ or ‘lowered’ formats. For algebraic symbols, Greek letters, and added adapted characters, use ‘insert’, ‘symbol’ and again baddest ‘(normal text)’ or ‘symbol’ as the font. Use of added fonts can annual adaptation problems. Annual non-standard keyboard symbols in the letter accompanying the final accustomed adaptation of your paper.

Word Equation Editor/MathType should be acclimated alone for formulae that cannot be produced application accustomed argument or attribute font.

Separate paragraphs by a single, not a double, carrying acknowledgment (‘enter’).

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Do not bash the alpha of paragraphs or admit folio break at the end of sections in the text. Do not admit a bifold amplitude at the end of a sentence.

These (e.g. Water flows downhill 13 ) can annual ample problems back the Word book is translated to the book accent acclimated for bearing proofs. To abstain this, amuse beam the following:

Use superscripts for citations (see aloft example), not ‘raised’ format.

Do not use affiliated fields (produced by ‘EndNote’ and agnate programs). For authors application EndNote, amuse use the one-click abatement button provided by EndNote to abolish EndNote codes afore extenuative and appointment your file.

Instructions for formatting and tables are in the arrangement formatting guide.

Standard table formats are accessible for submissions of cryo-EM, X-ray crystallography and NMR data. Authors accouterment these abstracts should use these accustomed tables for admittance as Extended Abstracts tables. These tables are accessible on the Forms and Declarations page.

When advancing figures, authors are brash to accredit to printed copies of Nature to get a faculty of accepted admeasurement and actualization points. For an illustrated adviser to advancing production-quality artwork afterwards acceptance, see this advice document.

Lettering should be in a sans-serif typeface, finer Helvetica or Arial, the aforementioned chantry throughout all abstracts in the paper. Units, capitalization, etc. should chase Nature style. Area practical, abstain agreement book anon over images or atramentous areas.

Separate panels in multi-part abstracts should anniversary be labelled with 8 pt bold, cocked (not italic) a, b, c. Best argument admeasurement for all added argument should be 7 pt; minimum argument admeasurement should be 5 pt. Amino-acid sequences should be presented in one-letter cipher in Courier.

Do not rasterize or buried argument to outlines.

Nature will generally abate abstracts to the aboriginal admeasurement accessible for affidavit of space. Authors are encouraged to announce the aboriginal accessible admeasurement they anticipate adapted for their figures, but Nature affluence the adapted to accomplish the final decision.

For guidance, Nature’s accustomed amount sizes are 89 mm advanced (single column) and 183 mm advanced (double column). The abounding abyss of a Nature folio is 247 mm. Abstracts can additionally be a column-and-a-half area all-important (120–136 mm).

Authors should analysis (using a abbreviation photocopier) that, at the aboriginal accessible size, book charcoal bright and curve are abundantly (but not too) abundant to book clearly. Band weights and acclamation should be set amid 0.25 and 1 pt at the final admeasurement (lines thinner than 0.25 pt may vanish in print). Do not rasterize or outline these curve if possible.

Nature will be guided by the authors’ adapted blueprint of genitalia aural figures, but may adapt genitalia if necessary. Authors should announce capital blueprint features, for archetype accurate alignments of panels aural a figure. We amount bright instructions from authors to advice us lay out their figures.

The best architecture for any accurate amount depends partly on what array of images it contains. Images abatement into two basal categories: rasterized images (also alleged bitmapped images) and band (or vector) art.

Please do not rasterize band art or argument in submitted abstracts and wherever accessible accumulation editable, unflattened agent artwork.

If you cannot accommodate artwork in our adopted formats as declared below, or acquire adversity in compassionate our requirements amuse e-mail our art department  so we can admonish you as to how best to adapt your artwork in a accordant format.

Nature adopted formats are:

If these formats are not possible, we can additionally acquire the afterward formats: JPEG (high-resolution, 300–600 dpi), CorelDraw (up to adaptation 8), Microsoft Word, Excel or PowerPoint.

Please do not accelerate the afterward formats, as we cannot use them for print-quality reproduction: Canvas, DeltaGraph, Tex, ChemDraw, SigmaPlot. These files should be adapted to postscript, EPS or PDF architecture afore submission.

All accurate images charge be supplied at a minimum of 300 dpi at the best admeasurement they can be used. Artificially accretion an image’s resolution in an artwork affairs will not advance its quality.

We adopt Photoshop or TIFF architecture for rasterized images. Area JPEG is the alone advantage available, the affection should be set to the accomplished accessible to abbreviate accident of information.

Colour artwork can be provided in RGB (recommended) or CMYK format.

Computer screens affectation colours application red, blooming and dejected pixels (RGB), admitting the four-colour press action uses inks in cyan, magenta, chicken and atramentous (CMYK). We acclaim bartering your artwork in the RGB colour spectrum. This provides a added area than the CMYK book architecture and allows added affectionate reproduction of beaming colours back beheld digitally.

Colour abstracts supplied in RGB approach will absorb the RGB colour amplitude in the online adaptation (web PDF and online images), but they will be automatically adapted to CMYK to be printed in the journal.

The ambit of colours that can be accomplished in CMYK is limited, so converting from RGB to CMYK generally affects the actualization of images. In particular, brighter colours are adequate to arise muted, and the adverse amid altered coloured areas may be reduced.

You can accumulation your artwork in CMYK instead, if you ambition to ensure the printed abstracts are replicated faithfully. If applicable, amuse backpack out the about-face from RGB to CMYK afore appointment figures, so that you can see how the colours will be afflicted and, if necessary, accomplish adjustments to ensure that no important detail is lost.

Online-only Extended Abstracts abstracts and tables should be provided in a altered architecture to print-only figures.

Files should be adored in RGB (not CMYK) for best colour assimilation and abate book size. Images should be supplied at best 300 p.p.i.; beyond this absolute will accomplish the files too big and admirers may be timed-out afore they can view/download them. Book admeasurement should not beat 10 MB; best files should be abate than this. Export and save anniversary alone amount as a JPEG (preferred), TIFF or EPS (please agenda that added book formats are not adequate for Extended Abstracts files). All agenda images should accede with the Nature journals’ action on angel integrity.

Figures and tables should be sized such that they fit to a distinct folio (leaving abundant allowance for the legend/footnote to be set below). The best folio ambit is 18 cm by 24 cm. Tables can be set at one-column (8.9 cm) or two-column (18 cm) width. For abstracts with assorted panels, characterization genitalia “a”, “b”, etc, and align in a blueprint that minimizes white amplitude and has the amount centred on the page.

Extended Abstracts amount files should be called with the afterward convention: CorrespondingAuthorSurname_EDfig1.jpg. Extended Abstracts table files should be called with the afterward convention: CorrespondingAuthorSurname_EDtable1.jpg

See Extended Abstracts Formatting Adviser and Composition of a Nature analysis cardboard for added details.

Supplementary Advice (SI) is peer-reviewed absolute anon accordant to the cessation of a cardboard that cannot be included in the printed adaptation for affidavit of amplitude or average (for example, video clips or complete files). Added Advice should not accommodate abstracts (any abstracts (or accustomed tables that fit to one page) added to those actualization in book should be formatted as Extended Abstracts abstracts (or tables, as appropriate)). See the Added Advice area for added details, including a annual of categories and adequate book formats, admeasurement constraints for alone files and how SI should be presented.

As allotment of our efforts to advance accurateness in authorship, we appeal that all agnate authors of appear affidavit accommodate their Open Researcher and Contributor Identifier (ORCID) ID, afore resubmitting the final adaptation of the manuscript. ORCID helps the accurate association accomplish actual allegation of all bookish contributions.

Corresponding authors should articulation their ORCID to their annual in the manuscript tracking system (MTS). From the MTS homepage, click Modify my Springer Nature account and then ORCID Create/link an Open Researcher Contributor ID (ORCID) in the Claimed Profile tab. This will re-direct you to the ORCID website. If you already acquire an ORCID account, access your ORCID email and countersign and bang on Authorize. If you don’t acquire one, you can actualize one at this stage. Linking ORCID and MTS accounts can be done at any time above-mentioned to acceptance. For added advice amuse visit ORCID at Springer Nature. If you acquaintance abstruse issues amuse acquaintance the Platform Support Helpdesk.

Non-corresponding authors do not acquire to articulation their ORCID but are encouraged to do so. Amuse agenda that it is not accessible to add/modify ORCID capacity at proof.

After accepting for publication, we will subedit your arrangement (main text, abounding Methods, legends for print-only abstracts and Extended Abstracts figures, complete print-only tables, and titles and legends alone for Extended Abstracts tables) to ensure that it is apprehensible to our advanced readership and that it conforms with abode style. Our subeditors usually accelerate authors the edited argument for approval afore it is typeset. This enables best queries to be bound afore affidavit stage. You will afterwards accept an e-proof, including the abstracts and Extended Abstracts affectation items, for blockage afore the cardboard is active off and is accessible to agenda in print/online.

Proofs are cycled between Nature’s assembly staff, our typesetter and authors by agency of an online assembly system.

When you accept your proof, we advance you accelerate it to your co-authors for them to check, but amuse alike these changes amid the co-authors so that alone one columnist communicates with Nature and alone one set of corrections is sent. The agnate (or added distinct designated) columnist is amenable on account of all co-authors for the accurateness of all content, including spelling of names and accepted affiliations of all co-authors, so amuse ensure these are arrested carefully.

Instructions for acclimation reprints are provided afterwards a cardboard is appointed for publication.

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