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Inivata Announces Accord with Maverick Therapeutics for use of RaDaR™ Assay

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RaDaR ctDNA aqueous biopsy analysis to be acclimated to adviser accommodating acknowledgment inPhase 1/2 abstraction of MVC-101 in assorted bump types

Research Triangle Park, NC, USA and Cambridge, UK, 29 October 2020 – Inivata, a baton in aqueous biopsy, today announces a accord with Maverick Therapeutics (“Maverick”) for the use of Inivata’s RaDaR™ appraisal for the apprehension and ecology of balance ache and recurrence. RaDaR will be acclimated to adviser circulating bump DNA (ctDNA) in patients enrolled in the Phase 1/2 abstraction of MVC-101, Maverick’s beforehand affairs candidate.

MVC-101 is Maverick’s lead, conditionally active, T cell-engaging COBRA™ atom advised to ambition Epidermal Growth Factor Receptor (EGFR), a protein bidding on both cancerous and advantageous tissues. As prodrugs, COBRAs are engineered to booty advantage of the bump microenvironment for T corpuscle activation, triggering T cell-mediated bump killing accurately at the armpit of the bump while sparing accident to the patients’ advantageous tissues. EGFR is bidding on a avant-garde ambit of solid tumors, including but not bound to colorectal, arch & neck, renal, pancreatic, cervical and non-small corpuscle lung cancers. Maverick expects to admit a Phase 1/2, accessible label, dosage accretion abstraction of MVC-101 in Q1 2021.

RaDaR is a alone appraisal that beforehand a set of up to 48 tumor-specific variants in a accommodating application a aqueous biopsy with aberrant sensitivity, acceptance both apprehension of balance ache afterward alleviative absorbed or absolute treatment, and aboriginal apprehension of relapse. As allotment of the MVC-101 analytic abstraction RaDaR will be acclimated to adviser acknowledgment in the balloon participants afterward analysis with MVC-101. These abstracts will accommodate admired aboriginal insights into the capability of this atypical bispecific belvedere and advice to acquaint both the affidavit of abstraction and recommended Phase 2 dose.

Peter Collins, Chief Business Officer of Inivata, commented: “The accord with Maverick is in band with our action to defended biopharma partnerships that beforehand RaDaR in analytic balloon settings to accredit beforehand acumen on the ability of biologic candidates for solid tumors. By accouterment admired acumen into a accurate patient’s ache state, the appraisal has the abeyant to accomplish analytic trials added focused and efficient.”

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Jeremiah Degenhardt PhD, Vice President of Translational Oncology & Bioinformatics at Maverick Therapeutics, commented: “ctDNA has apparent affiance as a predictive brand of aboriginal acknowledgment for immunotherapies in solid bump indications. The patient-specific architecture of the RaDaR appraisal enables the apprehension of balance ache with aberrant acuteness in assorted bump types and it is accordingly a awful commutual technology to beforehand our Phase 1/2 study. The use of RaDaR will accredit our aggregation to added accurately admeasurement analysis success throughout the balloon for our atypical COBRA platform.”

About InivataInivata is a baton in aqueous biopsy. Its InVision® belvedere unlocks capital genomic advice from a simple claret draw to adviser and personalize blight treatment, adviser acknowledgment and ascertain relapse. Inivata’s technology is based on beat analysis from the Blight Analysis UK Cambridge Institute, University of Cambridge. Its beforehand product, InVisionFirst®-Lung is commercially accessible internationally and through NeoGenomics in the US. It offers aggressive acuteness and turnaround, accouterment atomic insights that accredit clinicians to accomplish added abreast analysis decisions for avant-garde NSCLC patients. Inivata has additionally launched the alone RaDaR™ appraisal – acceptance the awful acute apprehension of balance ache and recurrence. Inivata is partnering with pharmaceutical, biotechnology companies and bartering ally in a ambit of aboriginal and backward date blight development programs. The Company has a CLIA certified, CAP accepted class in Analysis Triangle Park, NC and R&D laboratories in Cambridge, UK. For added information, amuse go to www.inivata.com. Follow Inivata on Twitter @Inivata.

About Maverick TherapeuticsMaverick Therapeutics is establishing itself as the baton in the chase to administer T corpuscle analysis to solid bump cancers by absorption abysmal chip ability in biologic development to architecture and bear a beat immunotherapy platform. Maverick’s awful avant-garde COBRA™ ameliorative belvedere is the best mature, conditionally alive bispecific T corpuscle agreeable belvedere advised to annihilate solid tumors. With COBRA, T corpuscle activation and consistent corpuscle killing alone booty abode area it is bare – in tumors. This different architecture delivers the continued approved afterwards trifecta in blight care; aerial specificity, aerial authority and bargain toxicity. Founded in 2016, Maverick is led by a aggregation of arch experts in protein engineering and T corpuscle ameliorative analysis and development. In aboriginal 2017, Maverick appear $125 actor of committed allotment from Takeda Pharmaceuticals (“Takeda”), MPM BioVentures 2014 and MPM Capital’s UBS Oncology Impact Fund. Based on the affiance of the Company’s early-stage research, Maverick entered a five-year biologic development activity with Takeda. For added information, amuse appointment www.mavericktx.com.

Media Contacts:Consilium Strategic CommunicationsChris Gardner/Angela Gray/Sarah WilsonPaul Kidwell (US)[email protected] 44 (0)20 3709 5700, 1 516 503 0271

Karen [email protected] 44 (0)7900 430235

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